Endocrine Abstracts

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a relatively recent and rare disease, frequently misdiagnosed. It is characterized as a generalized proliferation of pulmonary neuroendocrine cells and is recognized as a precursor lesion for pulmonary neuroendocrine tumors, although the risk of progression to malignancy is considered low. Here we report a patient with ectopic ACTH-dependent Cushing’s syndrome due to metastatic lung carcinoid tumors...

Introduction: The anatomical and physiological changes induced by bariatric surgery (BS) can significantly impact the absorption and pharmacokinetics of orally administered medication. In particular, levothyroxine (LT4) dosage, given its dependence on patient’s weight and gastric pH for optimal absorption, is expected to change following BS. However, the literature is not unanimous and there is a void of longer-term studies. We aimed to compare LT4 dosage 4 years followin...

Introduction: Obesity has been associated with increased androgenicity in women, however there are conflicting data on this subject. Objectives: To determine whether any androgen is independently related to body mass index (BMI), waist-to-hip ratio (WHR) or age. To access if there is an association between elevated plasma androgen levels and the presence of either morbid obesity or metabolic syndrome (MS).Design and Methods: A total of 148 obese women we...

A positive association between thyrotropin (TSH) secretion and body-mass index (BMI) was previously reported. There are many studies concerning thyroid function in obesity, and some of them describe higher TSH levels in obese subjects.Evaluation of the hypothyroidism prevalence in a sample of obese women in their first obesity appointment at Hospital São João.Anthropometric variables and serum levels of TSH, free triiodot...

Introduction: Bariatric surgery improves lipid profile. A still unanswered question is whether this improvement is merely weight dependent or also results from factors inherent to specificities of the bariatric procedure itself. We aimed to study lipid profile 1 year after bariatric surgery and compare its changes between the different procedures in patients matched for initial weight and for weight loss.Methods: We retrospectively analysed patients subm...

Introdution: Central diabetes insipidus(CDI) is a rare disease, with multiple aetiologies such as cranioencephalic traumatism and multiple sclerosis (ME). However, the association with ME is not commonly described. The clinical suspicion must be made in the presence of polyuria and polydipsia.Case report: Woman, 67 years-old, revealing history of ME relapsing-remitting subtype with 8 years of evolution, hypertension and dyslipidemia, medicated with inter...

Introduction: People with intracranial organic lesions, including pituitary tumours, may manifest initially as a psychiatric disorder, such as depression, emotional disturbance, anxiety, apathy, neurobehavioral disturbance, cognitive dysfunction and personality disturbance.Case Report: A male patient 45 years old was sent to the Department of Endocrinology of São João Hospital due to a pituitary macroadenoma. The patient referred asthenia, musc...

Introduction: Obesity is a heterogenous disorder. One of its subtypes that has been recently described is termed the metabolically healthy, but obese (MHO) individuals. Preliminary evidence suggests that this could be due to lower visceral fat levels and earlier onset of obesity.Objectives: To determine the prevalence of MHO in a sample of obese patients. To evaluate whether body mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR) are...

Introduction: Obesity is a growing worldwide public health issue and it is associated with multiple comorbidities, namely the so called Male Obesity-associated Secondary Hypogonadism (MOSH). However, the mechanisms that explain this association are not fully understood.Methods: Cross-sectional study of 163 obese men that were evaluated for several clinical and analytic parameters. Testosterone deficiency was defined as: total testosterone <2.8 ng/ml ...

Background: Bariatric surgery has been associated with a decrease in multiple obesity-related comorbidities including obstructive sleep apnoea syndrome (OSA). This study aims to access the OSA evolution in obese patients who underwent bariatric surgery.Methods: Retrospective longitudinal study of a population of obese patients who underwent bariatric surgery between January/2010 and July/2014 in our centre. Only patients who have undergone polysomnograph...